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10.24875/RIC.20000208 59 Vidal-AlaballJ.ButlerC

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Folate deficiency can have serious side effects, so treatment (especially during early pregnancy) is important

Vitamin B12 injections can cause issues with: Leg pain Muscle pain Muscle weakness Swelling in arms and lower extremities Swelling or pain in one leg Unstable walking Neurological Effects The neurological effects of vitamin B12 affect your brain

The foremost limitation is the absence of large-scale, randomized, and well-controlled clinical trials capable of establishing definitive evidence of safety and efficacy in human populations